GLUTAMINE PHOSPHORIBOSYL PYROPHOSPHATE AMIDOTRANSFERASE Meaning and
Definition
-
Glutamine phosphoribosyl pyrophosphate amidotransferase (GPAT) is an enzyme that plays a vital role in nucleotide biosynthesis, specifically in the synthesis of purine nucleotides. It is a critical component of the purine salvage pathway, which allows cells to recycle purine bases for the synthesis of new DNA and RNA molecules.
GPAT catalyzes the transfer of the amide nitrogen from glutamine to phosphoribosyl pyrophosphate (PRPP), resulting in the formation of 5-phosphoribosylamine and glutamate. This reaction is the first and rate-limiting step in the synthesis of purine nucleotides and serves as a crucial checkpoint for controlling their production within the cell.
The enzyme is typically found in the cytoplasm of both prokaryotic and eukaryotic cells. It is composed of multiple subunits, with the exact composition varying depending on the organism. The activity of GPAT is tightly regulated through several mechanisms, including feedback inhibition by end-products of the purine nucleotide pathway, such as AMP and GMP.
Defects in GPAT activity can lead to a variety of disorders, including immune deficiencies and genetic diseases like Lesch-Nyhan syndrome. In addition, targeting GPAT with specific inhibitors has been explored as a potential strategy for cancer treatment, as cancer cells often exhibit increased nucleotide biosynthesis to support their rapid proliferation.
Overall, glutamine phosphoribosyl pyrophosphate amidotransferase is a fundamental enzyme involved in nucleotide metabolism, and its proper functioning is crucial for maintaining cellular health and homeostasis.
Common Misspellings for GLUTAMINE PHOSPHORIBOSYL PYROPHOSPHATE AMIDOTRANSFERASE
- flutamine phosphoribosyl pyrophosphate amidotransferase
- vlutamine phosphoribosyl pyrophosphate amidotransferase
- blutamine phosphoribosyl pyrophosphate amidotransferase
- hlutamine phosphoribosyl pyrophosphate amidotransferase
- ylutamine phosphoribosyl pyrophosphate amidotransferase
- tlutamine phosphoribosyl pyrophosphate amidotransferase
- gkutamine phosphoribosyl pyrophosphate amidotransferase
- gputamine phosphoribosyl pyrophosphate amidotransferase
- goutamine phosphoribosyl pyrophosphate amidotransferase
- glytamine phosphoribosyl pyrophosphate amidotransferase
- glhtamine phosphoribosyl pyrophosphate amidotransferase
- gljtamine phosphoribosyl pyrophosphate amidotransferase
- glitamine phosphoribosyl pyrophosphate amidotransferase
- gl8tamine phosphoribosyl pyrophosphate amidotransferase
- gl7tamine phosphoribosyl pyrophosphate amidotransferase
- gluramine phosphoribosyl pyrophosphate amidotransferase
- glufamine phosphoribosyl pyrophosphate amidotransferase
- glugamine phosphoribosyl pyrophosphate amidotransferase
- gluyamine phosphoribosyl pyrophosphate amidotransferase
- glu6amine phosphoribosyl pyrophosphate amidotransferase
Infographic
Add the infographic to your website:
