CENPE Meaning and
Definition
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CENPE, an acronym for centromere-associated protein E, refers to a protein that plays a crucial role in the process of cell division. It is primarily involved in the proper alignment and segregation of chromosomes during both mitosis and meiosis. CENPE is specifically localized in the centromeres, which are specialized regions on chromosomes that ensure the accurate distribution of genetic material to daughter cells.
As an essential component of the kinetochore complex, CENPE binds to the centromere DNA and interacts with microtubules to facilitate the movement of chromosomes. By exerting tension and pulling force on the kinetochores, CENPE assists in aligning chromosomes at the metaphase plate during cell division. Furthermore, this protein contributes to the correction of any alignment errors that may occur, thereby preventing defects in chromosome segregation.
The proper functioning of CENPE is crucial for maintaining chromosomal stability and preventing aneuploidy, a condition characterized by abnormal chromosome numbers. Mutations or dysregulation of CENPE have been associated with various human diseases, including cancer. Therefore, CENPE is an important target for research aimed at understanding the molecular mechanisms underlying cell division and the development of potential therapeutic strategies.
In summary, CENPE is a centromere-associated protein that plays a vital role in the accurate distribution of chromosomes during cell division. It is involved in the alignment, segregation, and correction of chromosomes to ensure proper chromosomal stability.
Common Misspellings for CENPE
- cenpew
- cenpse
- cenpes
- cenp4e
- cenpe4
- cenp3e
- cenpe3
- ecnpe
- cepne
- ccenpe
- ceenpe
- cennpe
- cenpee
- aENPE
- CgNPE
- CEfPE
- CENPu
- CENPm
- c enpe
- ce npe
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