How Do You Spell APURINIC SITE?

1. Apurinic site refers to a specific location on a DNA molecule where a purine base (adenine or guanine) has been removed or is missing due to hydrolytic cleavage of the glycosidic bond between the sugar and the base.

   DNA is comprised of a sugar-phosphate backbone with nucleotide bases (adenine, guanine, cytosine, and thymine) attached to the sugar molecule. Under certain conditions, the glycosidic bond can break, resulting in a loss or removal of one of the bases. When this happens to a purine base, specifically adenine or guanine, it creates an apurinic site.

   These sites can occur naturally as a result of spontaneous depurination, wherein the DNA's hydrolysis reaction may cause the base to detach from the sugar. Additionally, they can be induced by chemical agents or enzymatic activity. Apurinic sites can also be formed through various DNA repair processes where specific enzymes or proteins recognize and remove damaged bases.

   Apurinic sites are of great interest in biological research due to their impact on DNA integrity and stability. They can lead to genetic mutations and cause structural alterations to the DNA molecule. Researchers often study apurinic sites to understand the mechanisms of DNA damage and repair, as well as their role in mutagenesis and carcinogenesis.

   To prevent further damage to the DNA, cells possess repair mechanisms that recognize apurinic sites and replace the missing base, ensuring the preservation of genetic information.

Common Misspellings for APURINIC SITE

The term "apurinic site" is derived from the Latin roots "a-" meaning "without", "purine", which refers to a type of nitrogenous base found in DNA and RNA, and "-ic" indicating a noun or adjective form. In molecular biology, an apurinic site, also known as an AP (apurinic/apyrimidinic) site, is a DNA or RNA site where the purine base (adenine or guanine) is removed or lost due to either chemical damage or enzymatic action. The term "apurine" signifies the absence of a purine base at the specific site.

Plural form of APURINIC SITE is APURINIC SITES

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