APOPROTEIN E Meaning and
Definition
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Apoprotein E, also known as ApoE, is a type of protein that plays a crucial role in the transport and metabolism of lipids (fats) in the body. It is synthesized and secreted primarily by the liver, but is also produced by other tissues, such as the brain and macrophages.
The ApoE protein acts as a ligand for various lipoprotein receptors, which enables the binding and uptake of lipoproteins by cells. It is involved in the transport of cholesterol, triglycerides, and other lipids in circulation, thereby participating in the regulation of lipid levels in the bloodstream.
ApoE exists in three major isoforms, designated as ApoE2, ApoE3, and ApoE4. Genetic variations in the ApoE gene determine the isoform an individual produces. The isoform composition of ApoE has been associated with different risks and susceptibility to various diseases, especially in relation to cholesterol metabolism and cardiovascular health. For instance, the ApoE4 isoform has been linked to an increased risk of developing Alzheimer's disease.
In addition to its role in lipid metabolism, ApoE also plays a significant role in various other physiological processes, including immune response, neuronal development, and repair. It has been implicated in neurodegenerative disorders, such as Alzheimer's disease and multiple sclerosis, where dysfunction or abnormal expression of ApoE may contribute to disease progression.
Overall, ApoE is a vital protein involved in lipid transport and metabolism as well as other cellular processes, making it an important target of research and potential therapeutic interventions.
Common Misspellings for APOPROTEIN E
- zpoprotein e
- spoprotein e
- wpoprotein e
- qpoprotein e
- aooprotein e
- aloprotein e
- a-oprotein e
- a0oprotein e
- apiprotein e
- apkprotein e
- aplprotein e
- appprotein e
- ap0protein e
- ap9protein e
- apoorotein e
- apolrotein e
- apo-rotein e
- apo0rotein e
- apopeotein e
- apopdotein e
Etymology of APOPROTEIN E
The term "Apoprotein E" is derived from the combination of two words: "apo" and "protein", followed by the letter "E".
The prefix "apo-" is derived from the Greek word "apó", meaning "away" or "separate". In the context of biochemistry, "apo-" is often used to denote a protein that has lost its associated prosthetic group or cofactor.
The word "protein" comes from the French word "protéine", which originally referred to a type of nutrient found in plant and animal tissues. It was coined in the 19th century by the Dutch chemist Gerardus Johannes Mulder.
The designation "E" in "Apoprotein E" represents the specific isoform or variant of the apolipoprotein protein.
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